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Discovery pipeline‚Äč

Working in close collaboration with our clinical and industry partners we have discovered biomarker signatures in several disease areas.

Our proprietary cluster-free, unbiased, and highly sensitive AI platform, ScaiVision, accelerates the pace of drug development. We can support you in almost every stage from discovery to translation into the clinics.

Together with our clinical and industry partners, Scailyte has discovered biomarker signatures in several disease areas.

Indication
Clinical question
Technology
Tissue
#patients
Outcome and Status
Sezary Syndrome (CTCL)
Diagnosis of CTCL
CyTOF
PBMCs
60 + 33
0.98 AUC; patent filed (EP19219889)
Flow-cytometry antibody panel prototype
Endometriosis
Diagnosis of endometriosis
scRNA-seq
PBMCs
42 + 60
0.9 AUC; patent filed (EP21204845)
Clinical validation and assay development
scRNA-seq
Endometrium
35 + 30
0.9 AUC; patent filed (EP21204856)
Clinical validation and assay development
Covid19 / ARDS
Prediction of ARDS development in Covid19-patients
CyTOF
PBMCs
Clinical data
37 + 17
0.95 – 1 AUC
Roussel et al., Cell Reports Medicine 2021
Head and neck squamous cell carcinomas (HNSCC) (Radiotoxicity)
Prediction of toxicity
CyTOF
PBMCs Clinical data
18
Correlation of 0.9 with toxicity scores.
Recruiting additional patients.
DLBCL (CAR-T Cells)
Prediction of therapy response and toxicity
scRNA-seq
Infusion cell product
23
0.8 AUC efficacy prediction
1 AUC toxicity prediction
Solid tumors
(tg T cells)
Prediction of therapy response
scRNA-seq
Infusion cell product
14
Correlation of r = 0.75 with measured response
Service project
Refractory rheumatoid arthritis
Treatment mode of action
scRNA-seq
Murine
hind-limbs
20
1.0 AUC
Service project
Solid tumors
(TIL therapy)
Prediction of therapy response and toxicity
CITEseq, TCRseq
Infusion cell product, PBMCs
55
ongoing
Service project
Solid tumors
(cancer vaccine)
Prediction of therapy response and toxicity
FC, IHC, proteomics, etc.
PBMCs, serum, tumor
20
ongoing
Service project
Helping you speed up your therapy development and increase your success rate