Deciphering Disease Mechanisms Through Functional Genomics

The research in Tiwari lab aims at achieving an integrated molecular and systems-level understanding of the communication between genetic and epigenetic information in determining cell identity and how this communication is altered in cancer and neurological disorders. To investigate these questions, Tiwari lab employs a multidisciplinary approach combining cutting-edge genomics and epigenetics together with computational biology tools in defined animal and cellular models. Most recently, using single-cell transcriptome profiles of TNBC patients, Tiwari lab has identified subclonal cell populations associated with chemoresistance. They further revealed the underlying gene regulatory circuitry and developed a first-in-class multi-gene assay for predicting chemotherapy response upfront for TNBC patients with high accuracy. Furthermore, they show that targeting these signature genes offers avenues to overcome resistance. These findings shed light on the mechanistic basis of chemoresistance while providing the best-in-class biomarker to predict chemotherapy response and alternate therapeutic routes for improved management of TNBC patients resistant to chemotherapy.

The format is the following:

• 5 mins – introduction
• 30 mins – main discussion
• 10 min+ – Q&A

Tickets: https://www.eventbrite.com/e/deciphering-disease-mechanisms-through-functional-genomics-tickets-578603728327