ScaiDigest July 2023

“Application of Single-cell and multi-omics technologies in CAR T cell therapy

Chimeric antigen receptor (CAR) T cell therapy approaches have shown great potential to introduce a significant change to the treatment of cancer. However, the therapy’s full potential is yet to be unlocked as the scientific community is still learning about the intricacies of the mechanism of action, clinical implications and in vivo activity.

Single-cell and multi-omics approaches could be the key to unlocking the full potential of CAR T therapy and optimizing the therapy’s safety and efficacy as the approaches become more widely used. The full extent of using such approaches is highlighted in the works of Barboy et al. and Yang, Chen and Han.

The utilization of multi-omics data at single-cell resolution provides scientists with an immense amount of data which could be applied in different ways such as enhancing the efficacy of CAR T cell therapy, determining optimal CAR targets and minimizing the CAR T cell-related toxicities. Furthermore, the use of computational approaches, like machine learning and artificial intelligence, has been highlighted as the method of expediting the integration of multi-omics data in both discovery and clinical evaluation.”  

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212274/

https://aacrjournals.org/cancerdiscovery/article-abstract/13/7/1546/727638/In-Synergy-Optimizing-CAR-T-Development-and